Abnormal Aggregation and Increased Size of Platelets in Myeloproliferative Disorders

Summary

Platelet aggregation is frequently impaired in myeloproliferative disorders (MPD). The presence of spontaneous platelet aggregation (SPA) or alterations of the aggregation pattern after ADP, epinephrine and collagen have been a frequent feature in the series of 52 patients here presented. The occurrence of SPA was not related to the findings obtained with the aggregating agents or to the number of circulating platelets. The aggregation results did not correlate with the number of megathrombocytes.

The presence of platelet abnormalities, not completely corrected after busulfan therapy, and the increased size of platelets should aid in diagnosis of myeloproliferative disorders.

Keywords

Platelet aggregation - Myeloproliferative disorders - Platelet size - Platelet function after busulfan

• References

• 1 Spaet TH, Lejuicks I, Gaynor E, Goldstein L. Defective platelets in essential thrombocythaemia. Arch Intern Med 1969; 124: 135-141
• 2 Cardamone JM, Edson JR, McArthur JR, Jacob HS. Abnormalities of platelet function in the myeloproliferative disorders. Amer Med Ass 1972; 3: 270-273
• 3 Berger S, Aledort LM, Gilbert HS, Hanson JP, Wasserman L. Abnormalities of platelet function in polycythaemia vera. Cancer Res 1973; 33: 2683-2687
• 4 Walsh PN, Murphy S, Barry WE. The role of platelet in the pathogenesis of thhrombosis and haemorrhage in patients with thrombocytosis. Thromb Haemostas 1977; 38: 1085-1096
• 5 Vreeken J, Van Aken WG. Spontaneous aggregation of blood platelets as a cause of idiopathic thrombosis and recurrent painful toes and fingers. Lancet 1971; I: 1394-1397
• 6 Barbui T, Battista R, Dini E. Spontaneous platelet aggregation in myeloproliferative disorders. A preliminary study. Acta Haemat 1973; 50: 25-29
• 7 Cortelazzo S, Barbui T, Viero P, Bassan R, Dini E, Ferro MiloneF. Platelet malonyldialdehyde and spontaneous aggregation during ischaemic attacks of patients with polycythaemia vera. Thromb Haemostas 1979 in press
• 8 Karpatkin S. Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. Blood 1978; 51: 307-316
• 9 Born GV R. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927-929
• 10 Zeigler Z, Murphy S, Gardner FH. Microscopic platelet size and morphology in various haematological disorders. Blood 1978; 51: 479-486
• 11 Garg SK, Amorosi EL, Karpatkin S. Use of the megathrombocyte as an index of megakariocyte number. New Engl J Med 1971; 284: 11-17
• 12 Packham MA. Methods for detection of hypersensitive platelets. Thromb Haemostas 1978; 40: 175-195
• 13 Pareti FI, Mannucci PM, Asti D, Guarini A, Gugliotta L, Tura S. Acquired storage pool disease in myeloproliferative disorders. Thromb Haemostas (Abstract) 1979; 42: 44